Peripheral blood lymphocytes were electron microscopically studied in patients with disseminated drug-sensitive and drug-resistant pulmonary tuberculosis before and during specific antituberculous chemotherapy. There was a tendency for an increase in the count of lymphocytes with membranous morphostructural changes during the therapy, which was more clearly defined in the drug-resistant type of the infectious process. It is suggested that antituberculous drugs have a damaging effect on the membrane of immunocompetent blood cells.
View Article and Find Full Text PDFFiziol Zh Im I M Sechenova
October 1994
Farmakol Toksikol
September 1990
The pharmacodynamics, antiarrhythmic activity and tolerance of bonnecor were studied in 25 patients with acute myocardial infarction (AMI) and 23 patients with chronic ischemic heart disease (IHD) complicated by cardiac rhythm disorders in the form of extrasystoles. Extrasystoles were revealed in 92% of AMI patients at a single administration of bonnecor and in 82.5% of IHD patients at long-term oral administration of the drug.
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