[Redox-potential of blood and consistence of energoproviding defence system in cytomegalovirus infection in pregnancy].

We have studied the relationship between the hypoxic change and mitochondrial redox-potential disturbances in the mechanism of pheto-placental insufficiency in pregnancy with cytomegalovirus infection (CMV), detected by the positive anti-CMV-IgG titer and more then 4-fold increase of low avid anti-CMV-IgG. It was shown, that chronic CMV infection induces production of active forms of oxygen, peroxidation of structures and concurrently damage of mitochondria with essential decrease of ATP level. Results of the study have shown the important diagnostic value of estimation of hypoxic-oxidative damage induced by CMV infection.

Pharmacological correction of changes in the lung-placenta system under experimental conditions.

Pathological changes in the fetoplacental complex and lung-placenta system were observed in rats with experimental gestosis produced by long-term feeding of a high-sodium diet. We revealed a decrease in the weights of the placenta and fetus, pulmonary fibrinolytic dysfunction, and increased production of cortisol. The course of fraxiparine treatment in animals with experimental gestosis decreased coagulation activity of the arterial blood, increased the weights of the placenta and fetus, and reduced the concentration of stress hormone cortisol.