Publications by authors named "M A Raabe"
Introduction: Root caries (RC) remains a global health problem leading to negative impacts on an elderly person's well-being causing oral health-related quality of life issues, as inadequate nutrition and detrimental oral functionality. The present systematic review with meta-analysis is designed to synthesize existing research findings on the prevalence and experience of root caries globally over the past 30 years. It aims to describe its distribution by country and explore its links with various socioeconomic indicators.
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- Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) resembles viral responses, affecting tumor cells and their microenvironment.
- A study on 46 primary tumors revealed that high repeat RNA levels correlate with changes in cell identity in both PDAC cells and cancer-associated fibroblasts (CAFs).
- The distinct immune signaling pathways in PDAC and CAFs, particularly involving interferon regulatory factor 3 (IRF3), highlight how these viral-like responses impact cellular flexibility and interactions within the tumor environment.
Background: HCC is a highly vascular tumor, and many effective drug regimens target the tumor blood vessels. Prior bulk HCC subtyping data used bulk transcriptomes, which contained a mixture of parenchymal and stromal contributions.
Methods: We utilized computational deconvolution and cell-cell interaction analyses to cell type-specific (tumor-enriched and vessel-enriched) spatial transcriptomic data collected from 41 resected HCC tissue specimens.
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- UV crosslinking with mass spectrometry (XL-MS) helps identify proteins that bind to RNA and DNA, revealing their specific domains and amino acids.
- The study introduces NuXL, a search engine designed to efficiently analyze nucleotide-protein crosslinks at a detailed amino acid level, enhancing the understanding of protein interactions.
- This approach increases crosslinked protein yield significantly, providing valuable insights into the structural features and binding properties of over 1500 nucleic acid-binding proteins, including transcriptional regulators.
Cerebral perforators are end-arteries that vascularize specific deep territories in the cerebral hemispheres and brainstem. Due to improved imaging quality, these aneurysms are increasingly diagnosed in clinical routine. High resolution 3D angiographic images are mandatory and in some occasions fusion images might be helpful to detect these aneurysms.
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