Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai.

Hakai protein (CBLL1 gene) was identified as an E3 ubiquitin ligase of E-cadherin complex, inducing its ubiquitination and degradation, thus inducing epithelial-to-mesenchymal transition. Most of the knowledge about the protein was associated to its E3 ubiquitin ligase canonical role. However, important recent published research has highlighted the noncanonical role of Hakai, independent of its E3 ubiquitin ligase activity, underscoring its involvement in the N-methyladenosine (mA) writer complex and its impact on the methylation of RNA.

Applying the LATER model to reaction time data: an open-source toolkit.

Analyzing reaction time distributions can provide insights into decision-making processes in the brain. The Linear Approach to Threshold with Ergodic Rate (LATER) model is arguably the simplest model for predicting reaction time distributions and can summarize distributions with as few as two free parameters. However, the coordinates for visualizing and fitting distributions with LATER ("reciprobit" space) are irregular, making the application of this simple model inaccessible to those without a programming background.

Temporal dynamics of Legionella (Proteobacteria, Legionellaceae) in two Pampean shallow lakes from Argentina.

Aquatic systems have traditionally played a key role in the development of human life, providing multiple ecosystem services to society and being a reservoir for a wide biodiversity of organisms. Among them, bacteria belonging to Legionella stand out, mainly because they are of great interest both in the field of microbial ecology and public health, since some of them turn out to be pathogenic for humans. The aim of this work was to study the monthly temporal dynamics of Legionella spp.