Publications by authors named "M A Puerto"
Dodecyl amine functionalized reduced graphene oxide (DA-rGO) and [2-(methacryloyloxy) ethyl] trimethylammonium chloride functionalized rGO (MTAC-rGO) have been developed and characterised for their further use in the food packaging industry as food contact materials. But before their application, an authorization procedure is required in which their safety plays a key role. Therefore, the aim of this work was to evaluate their toxicity with focus on two different toxicity mechanisms: genotoxicity and immunotoxicity.
View Article and Find Full Text PDFThe potential endocrine disruption activity of cyanotoxins, particularly their effects on estrogen and androgen receptors (ER, AR), remains poorly understood. In the present study, the potential agonistic/antagonistic estrogenic and androgenic activities of MC-LR and CYN have been determined for the first time with validated OECD Test Guidelines No. 455 and 458, respectively.
View Article and Find Full Text PDFArticle Synopsis
- - Functionalized graphene materials, like DA-rGO and MTAC-rGO, are considered for use as nanofillers in food packaging due to their ability to enhance the properties of the resulting products.
- - Toxicity evaluations of these materials showed decreased cell viability and oxidative stress in Caco-2 and HepG2 cell cultures when exposed to concentrations above 100 μg/mL.
- - Both materials exhibited increased cytotoxicity after undergoing an in vitro digestion process, highlighting potential risks associated with their use in food contact applications, warranting further research.
Article Synopsis
- Chromosome pairing is crucial for genome organization, but the mechanisms in somatic cells, particularly in Drosophila, are not well understood, despite their pronounced pairing features.
- The study identifies two factors that influence the localization of CAP-H2, an anti-pairing protein, particularly focusing on Z4's role in its function at architectural protein binding sites (APBSs).
- Additionally, they discover that osmotic stress can cause rapid unpairing of chromosomes, emphasizing the relationship between chromosome pairing and different types of 3D interactions within the genome.