Publications by authors named "M A Posner"
Situational factors can influence cognitive performance and should be considered for conducting cognitive assessments. The objective of this project was to develop a checklist for Cognitive Assessment Requirements (CARE) to identify these situational factors before conducting cognitive assessments and account for them. This study employed a four-round Delphi approach involving 22 experts to identify situational factors that can impact cognitive assessment results.
View Article and Find Full Text PDFThe 50th birthday of the JEP: Human Perception and Performance is an appropriate occasion to salute its influence in the field. In this celebratory article, the author tries to trace some of the work reported in Volume 1 to current research. He hopes that this might be inspirational to some of its readers.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on brain metastasis (BM) in patients with head and neck squamous cell carcinoma (HNSCC), analyzing 61 cases from various institutions to understand their molecular characteristics and immune responses.
- Key findings included that most patients were around 59 years old, with a significant number being HPV-positive and showing frequent genetic alterations like ATM, KMT2A, and TP53, which are potential therapeutic targets.
- The research revealed low densities of immune cells in BM samples and a median survival of 9 months post-diagnosis, suggesting areas for future research in immunotherapy and better treatment strategies.
INSM1 has rapidly emerged as a robust marker for neuroendocrine (NE) differentiation, prompting the use of INSM1 as a standalone marker for NE differentiation in various sites. INSM1 staining could be an especially practical tool for evaluating HPV-associated oropharyngeal squamous cell carcinoma (HPV-OPSCCs) because high-grade NE transformation may be exceedingly difficult to recognize on morphologic grounds alone, even though it portends highly aggressive clinical behavior. The purpose of this study was to determine the incidence of INSM1 expression in HPV-OPSCC and study its role in determining NE transformation and clinical aggressiveness.
View Article and Find Full Text PDFDiagnostic Accuracy of Circulating Tumor HPV DNA Testing in Patients With a Lateral Neck Mass.
JAMA Otolaryngol Head Neck Surg
September 2024
Importance: The most frequent presenting symptom for patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a lateral neck mass. Circulating tumor tissue-modified viral (TTMV)-HPV DNA is a unique biomarker produced by the fragmentation of HPV DNA during the degradation of HPV-associated tumors, and its detection and quantitation are currently being used as an adjunct to imaging in monitoring for disease recurrence and may have utility for diagnosis.
Objective: To measure the diagnostic characteristics of TTMV-HPV DNA compared with gold standard tissue biopsy for diagnosing HPV-OPSCC in patients presenting with an indeterminate lateral neck mass.