Developing Topics.

Background: The Alzheimer's Disease Colombian kindred is the world's largest autosomal dominant cohort with Early Onset Familiar Alzheimer's Disease (EOAD) due to a single genetic variant. These families have been studied for decades, identifying the disease progression from early subclinical stages to late dementia stages. Such cognitive and functional decline impacts the mental and physical well-being of families and caregivers and to our knowledge, how being part of these families affects reproductive desire and contraception has not been studied.

Drug Development.

Background: Acetylcholine, a neurotransmitter critical for cognitive functions, including attention, memory, and sociability, is essential for maintaining synaptic integrity. Deficits in acetylcholine levels are linked to cognitive impairments. Heterozygous VAChT KD (VAChT KDHET) mice, characterized by reduced vesicular acetylcholine transporter protein production, exhibit cognitive impairments due to diminished acetylcholine release.

Comparison of Sulfamethoxazole Removal Efficiency Using Polyethersulfone Ultrafiltration Membrane Modified by Various Methods.

Nowadays, there is a growing interest in membrane modification processes to improve their characteristics and the effectiveness of their treatments and reduce the possible fouling. In this sense, in this work, a modification of an ultrafiltration membrane with three different materials has been carried out: reduced graphene oxide (rGO), chitosan and MgCl. For both the native and the modified membranes, a study has been carried out to remove the emerging contaminant sulfamethoxazole (SMX).

Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.

Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.

Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.

A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology.

The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. Cell size and shape have been informative in defining macrophage subtypes. Studies show pro and anti-inflammatory macrophages exhibit distinct migratory behaviors, in vitro, in 3D and in vivo but this link has not been rigorously studied.