Publications by authors named "M A Piris Pinilla"
Introduction: The cognitive side-effects of medication are common, but often overlooked in practice, and not routinely considered in interventional trials or post-market surveillance. The cognitive footprint of a medication seeks to quantify the impact of its cognitive effects based on magnitude, duration, and interaction with other factors, evaluated across the exposed population.
Methods: Bayesian multivariable regression analysis of retrospective population-based cross-sectional cohorts.
Pharmacokinetics and safety of bictegravir in pregnant and postpartum persons with HIV and their infants.
J Acquir Immune Defic Syndr
November 2024
Background: Limited data exist on bictegravir pharmacokinetics in pregnancy among persons with HIV (PWH) and infant washout.
Setting: Nonrandomized, open-label, multi-center phase-IV prospective study of bictegravir pharmacokinetics and safety in pregnant PWH and their infants.
Methods: Steady-state 24-hour pharmacokinetic sampling of oral bictegravir 50 mg once daily (a component of fixed-dose combination bictegravir/emtricitabine/tenofovir alafenamide) during the 2nd and 3rd trimesters and postpartum was performed.
Purpose: To generate an evaluation checklist for the multidisciplinary approach to patients with asthma or suspected asthma.
Patients And Methods: This was a qualitative study based on a literature review and expert opinions. A multidisciplinary steering committee with knowledge and experience in asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) was established and comprised two pneumologists, two allergologists, and two otorhinolaryngologists.
Article Synopsis
- Congenital anemias are diverse disorders caused by abnormalities in red blood cells and can involve defects in enzymes, membranes, and hemoglobin, presenting with varying severity and symptoms.
- The study utilized Quant 3' mRNA-Sequencing to analyze gene expression in patients with sickle cell disease, thalassemia, and a rare form of congenital sideroblastic anemia (CSA), revealing distinct gene expression patterns.
- Results indicated that most congenital anemias showed upregulated genes related to metabolic processes and erythropoiesis, while the CSA patient exhibited a unique gene map, highlighting the clinical significance of these findings in understanding anemia mechanisms.
Article Synopsis
- The study investigates the CT features of Morel-Lavallée lesions (MLLs) in cats, focusing on their occurrence following trauma and their unique fluid characteristics.
- Three young cats with recurrent swelling after pelvic limb trauma were examined, all showing fluid-filled spaces between the dermis and deep fascia.
- MLLs can be easily misdiagnosed due to similar appearances to other injuries, posing risks like significant skin necrosis if not treated properly.