Zinc Influences the Efficacy of Betulinic Acid Treatment and Radiotherapy in Breast Cancer Cells.

The trace element zinc influences a number of biological reactions, including cell growth, apoptosis, and DNA damage, which affect tumor therapy. The natural compound betulinic acid (BA) and its derivatives are known for their antiviral, antibacterial, and antitumor effects. Previous studies show that BA and 3-acetyl-28-sulfamoyloxybetulin (CAI3) have high cytotoxicity and induce radiosensitization in breast cancer cells.

Some aspects of the diagnosis and treatment of eosinophilic granuloma in cats.

Introduction: Eosinophils represent the most active cells in mammals that show protective and assistive activity in the host immune defence against helminth parasites. These cells are also responsible for the reduction of allergic and inflammatory reactions. The eosinophils play a key role in allergic reactions by secretion of different chemical molecules leading to swelling, lesions and granuloma onset.

SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells.

Betulinic acid (BA) is a natural compound well known for its anti-inflammatory, anti-viral, anti-bacterial, anti-malarial effects and anti-tumor properties. Its enhanced cytotoxicity in tumor cells and induction of cell death in various cancer entities qualifies BA as an interesting candidate for novel treatment concepts. Our analyses showed enhanced cytotoxicity and radiosensitization under hypoxic conditions in human breast cancer cells.

Towards a Practical Implementation of a Single-Beam All-Optical Non-Zero-Field Magnetic Sensor for Magnetoencephalographic Complexes.

We present a single-beam all-optical two-channel magnetic sensor scheme developed for biological applications such as non-zero-field magnetoencephalography and magnetocardiography. The pumping, excitation and detection of magnetic resonance in two cells are performed using a single laser beam with time-modulated linear polarization: the linear polarization of the beam switches to orthogonal every half-cycle of the Larmor frequency. Light with such characteristics can be transmitted over a single-mode polarization-maintaining fiber without any loss in the quality of the polarization characteristics.