Transforming the Medication Regimen Review Process Using Telemedicine to Prevent Adverse Events.

Background/objectives: Federally-mandated consultant pharmacist-conducted retrospective medication regimen reviews (MRRs) are designed to improve medication safety in nursing homes (NH). However, MRRs are potentially ineffective. A new model of care that improves access to and efficiency of consultant pharmacists is needed.

Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials.

In vitro measurements of skin absorption are an increasingly important aspect of regulatory studies, product support claims, and formulation screening. However, such measurements are significantly affected by skin variability. The purpose of this study was to determine inter- and intralaboratory variation in diffusion cell measurements caused by factors other than skin.

The effect of beta-cyclodextrins on the permeation of diclofenac from supersaturated solutions.

Supersaturation is a very useful method of enhancing the permeation of drugs across membranes such as skin, because unlike other methods, it does not interfere with the ultrastructure of the stratum corneum. Many drugs are able to form inclusion complexes with beta-cyclodextrins (beta-CDs) and this study investigates the anti-nucleating effects of these compounds on supersaturated solutions of diclofenac. The ability of various betaCDs to form inclusion complexes with diclofenac was assessed by measuring their saturated solubilities.

The back diffusion of glucose across human skin in vitro.

For diabetic patients, blood glucose monitoring is an important part in the management of their disease, however the acquisition of blood requires the use of invasive and often painful methods, and the development of a technique that removes these problems would represent a major advance. The uppermost membrane of the skin, the stratum corneum, has been shown to be the main barrier to percutaneous absorption, but there have been claims that polar water-soluble compounds diffuse across it via aqueous pathways. In this study, skin diffusion cells were used to investigate the back diffusion of tritiated water and the convective transport of 3H-glucose across full thickness human skin after the application of a number of different materials to the stratum corneum.