Publications by authors named "M A Pagel"
Purpose: Preclinical models of cutaneous wound healing can be useful for improving clinical wound care. Oxygen Enhanced Photoacoustic imaging (OE PAI) can measure oxygenation, and Dynamic Contrast Enhanced (DCE) PAI can measure vascular perfusion. We investigated how a combined OE-DCE PAI protocol can measure vascular oxygenation and perfusion to a cutaneous healing model.
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- Tumor hypoxia in pediatric malignant rhabdoid tumors (MRT) leads to resistance against radiation therapy, worsening treatment outcomes.
- Researchers repurposed an FDA-approved drug, Atovaquone (AVO), to reduce oxygen consumption in tumors, enhancing their sensitivity to low-dose radiation therapy.
- Using multispectral optoacoustic tomography (MSOT), they monitored oxygen levels in tumors, finding that AVO increased oxygen saturation before radiation treatment, which correlated with improved anti-tumor responses, while resistance to AVO diminished its effectiveness.
Purpose: Electron Paramagnetic Resonance Imaging (EPRI) can image the partial pressure of oxygen (pO) within in vivo tumor models. We sought to develop Oxygen Enhanced (OE) EPRI that measures tumor pO with breathing gases of 21% O (pO) and 100% O (pO), and the differences in pO between breathing gases (ΔpO). We applied OE EPRI to study the early change in tumor pathophysiology in response to radiotherapy in two tumor models of pancreatic cancer.
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