[Gastroesophageal reflux after laparoscopic hiatal hernia repair in patients with axial hiatal hernia].

Objective: To find out significance of the main locking mechanisms of lower esophageal sphincter in the relapse of GERD in patients with axial hiatal hernia after previous antireflux laparoscopic surgery.

Material And Methods: There were 103 patients with GERD and axial hiatal hernia who underwent original circular laparoscopic esophagofundoplication with correction of hiatal opening dimensions by crural and hiatal repair. Depending on generalized DeMeester index (within the normal range or its excess), all patients were divided into two groups - without relapse (group 1, =88) and with recurrent GERD (group 2, =15).

High resolution manometry and new classification of esophageal motility disorders.

Aim: To present application of Chicago classification criteria of esophageal motility disorders defined in high resolution manometry in clinical practice.

Materials And Methods: High-resolution manometry is the most exact hi-tech diagnostic method for esophageal motor function disorders according to Chicago classification v3.0.

[Possibilities of pH impedance and high-resolution manometry in managing patients with refractory gastroesophageal reflux disease].

Gastroesophageal reflux disease (GERD) is a common condition that has a substantial impact on quality of life in patients and is a leading risk factor for esophageal adenocarcinoma. Now therapy with proton pump inhibitors (PPIs) is a basic method in the treatment of patients with GERD; however, one third of the patients do not respond to the therapy used. The causes of refractory GERD are a fairly large group of heterogeneous factors contributing to the inefficacy of PPIs in adequate dosage.

[Activa tion of the complement system by the classical and alternative pathways in prolonged type 2 diabetes mellitus].

The study was undertaken to assess the functional activity of the classical and alternative pathways of complement activation in type 2 diabetes mellitus (DM-2) at late stages of the disease. For this purpose, the total hemolytic activity of the classical and alternative pathways of complement activation and the hemolytic activities of the complement components C1, C2, C3, and C4 were determined in the blood of patients with DM-2 and healthy individuals. According to the data obtained, patients with DM-2 at late stages of the disease have statistically significant increases in both the total hemolylical activity of the classical pathway of complement activation (by 1.