Atorvastatin improves sputum conversion and chest X-ray severity score.

We report the results of a phase IIB study investigating the safety and effectiveness of atorvastatin use with standard anti-TB drugs. In this multicentre, open-labelled study, we recruited treatment-naÏve patients with uncomplicated pulmonary TB aged at least 18 years. Participants were randomly assigned to standard-of-care or standard-of-care plus oral dose of atorvastatin (40 mg) daily for 2 months.

Mean quality of life of hypertensive and diabetic patients: A comparative study of patients in secondary and tertiary health facilities in Kaduna State, Nigeria.

Introduction: Hypertension and diabetes have become major non-communicable diseases of public health importance globally, considering the magnitude of the diseases, the propensity to worsen the patients' quality of life and the associated mortality. This study compared the health-related quality of life (HRQOL) of hypertensive and diabetic patients in both tertiary and secondary health facilities in Kaduna State, north-western Nigeria.

Materials And Methods: This was a descriptive comparative cross-sectional study amongst 325 patients, of which 93 (28.

Assessment of Utilization of Post Exposure Prophylaxis (PEP) among HIV-Exposed Individuals in a Tertiary Hospital, Northwest Nigeria.

Background: Human Immunodeficiency Virus (HIV) post-exposure prophylaxis (PEP) has been documented to be effective in preventing HIV in exposed individuals. World Health Organization (WHO) recommends that every individual exposed should be treated within 72hours. We aimed to assess the utilization of PEP among clients in a tertiary facility in Northwest, Nigeria.

Syntheses of L-Rhamnose-Linked Amino Glycerolipids and Their Cytotoxic Activities against Human Cancer Cells.

A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable L-glucosamine-based glycosylated antitumor ether lipids (GAELs) that were cytotoxic to chemotherapy-resistant cancer cells. In the absence of commercially available L-glucosamine, many steps were needed to synthesize the compound and the overall yield was poor.