Publications by authors named "M A Oghabian"
Background: Obstructive sleep apnea (OSA) is characterized by disruptive breathing, resulting in a decline in cognitive performance. This study investigates the role of oxygen extraction fraction (OEF) and quantitative susceptibility mapping (QSM) in OSA-related cognitive impairment.
Methods: The study recruited 15 patients with confirmed OSA and 16 healthy controls, who underwent overnight polysomnography and brain MRI using a 3 Tesla machine and 64-channel head coil.
Introduction: Cue-induced craving is central to addictive disorders. Most cue-reactivity functional magnetic resonance imaging studies are analyzed statically and report averaged signals, disregarding the dynamic nature of craving and task fatigue. Accordingly, this study investigates temporal dynamics of the neural response to drug cues as a functional magnetic resonance imaging study among methamphetamine users.
View Article and Find Full Text PDFBackground: Obstructive sleep apnea (OSA) is a prevalent sleep disorder that is associated with structural brain damage and cognitive impairment. The hypothalamus plays a crucial role in regulating sleep and wakefulness. We aimed to evaluate hypothalamic subunit volumes in patients with OSA.
View Article and Find Full Text PDFBackground & Aim: The histologic and molecular changes from intestinal metaplasia (IM) to gastric cancer (GC) have not been fully characterized. The present study sought to identify potential alterations in signaling pathways in IM and GC to predict disease progression; these alterations can be considered therapeutic targets.
Materials & Methods: Seven gene expression profiles were selected from the GEO database.
Article Synopsis
- The study reviews the last 25 years of functional magnetic resonance imaging drug cue reactivity (FDCR) research, highlighting the gap between findings and clinical applications as no FDCR-derived biomarkers have been approved yet.
- The objective is to summarize FDCR research, evaluate its readiness for biomarker development, and propose a systematic process for qualifying these biomarkers in the context of addiction treatment.
- Out of 415 published FDCR studies from 1998 to 2022, a significant number explored addictive substances like nicotine and alcohol, suggesting potential for developing various types of biomarkers related to addiction, though most studies mainly focused on therapeutic and diagnostic responses.