Publications by authors named "M A O'Connell"
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key regulator of cell detoxification, which maintains homoeostasis in healthy cells and promotes chemoresistance in cancer cells. Controlling the expression of this transcription factor is therefore of great interest. There are many compounds that have been shown to induce Nrf2 expression, but ligands that can inhibit Nrf2 are scant.
View Article and Find Full Text PDFIntroduction: Dual-task (DT) exercises combine both physical and cognitive activities and have the potential to efficiently enhance both physical and cognitive function.
Background/objectives: This study aimed to determine if, compared with exercise-only (EO) and control (C) groups, adults in a DT training program improved measures of cognitive and/or physical functioning.
Methods: Thirty-five participants (Mage = 65.
Young adults with early psychosis often disengage from essential early intervention services (i.e., Coordinated Specialty Care or CSC in the United States).
View Article and Find Full Text PDFThe precise and unambiguous detection and quantification of internal RNA modifications represents a critical step for understanding their physiological functions. The methods of direct RNA sequencing are quickly developing allowing for the precise location of internal RNA marks. This detection is however not quantitative and still presents detection limits.
View Article and Find Full Text PDFObjective: To investigate inequities in time-to physical therapy for patients with low back pain.
Design: Retrospective observational study utilizing data from the Department of Defense and Veterans Health Administration clinical and administrative data repositories derived from medical records, claims, and enrollment data.
Setting: Military Health System, Veterans Health System, and civilian healthcare facilities.