Publications by authors named "M A Novikova"
Aging is a complex process associated with multimorbidity. Hypertension, one of widespread states, is among main causes of age-related alterations in behavior, emotionality and sociability. We studied the effects of long-term isolated housing on anxiety, depressive-like and social behavior as well as changes in the adrenocortical and sympathetic systems in the aging normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR).
View Article and Find Full Text PDFBackground/objectives: Aging and chronic stress are regarded as the most important risk factors of cognitive decline. Aged spontaneously hypertensive rats (SHRs) represent a suitable model of age-related vascular brain diseases. The aim of this study was to explore the effects of chronic isolation stress in aging SHRs on their cognitive functions and response to acute stress, as well as the influence of the chronic oral intake of N-Pep-Zn, the Zn derivative of N-PEP-12.
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- The study aimed to analyze clinical data from patients with non-obstructive ischemic heart disease (IHD) and multifocal atherosclerosis (MFA) in the KAMMA registry, focusing on those who underwent coronary angiography (CAG).
- Out of 1,893 IHD patients, only 8.7% had non-obstructive coronary atherosclerosis (CA), with many affected by MFA in various arteries, especially the brachiocephalic and lower extremity arteries.
- Patients with non-obstructive CA, predominantly women, had fewer traditional risk factors like smoking and diabetes, but higher cholesterol levels; they also experienced less severe IHD and acute coronary syndrome compared to those with obstructive
[Predictors of the efficacy of non-drug treatments for non-dementia vascular cognitive impairment].
Zh Nevrol Psikhiatr Im S S Korsakova
June 2023
Objective: To study the predictors of the efficacy of non-drug multimodal therapy in the treatment of mild vascular cognitive impairment.
Material And Methods: Thirty patients with mild vascular cognitive impairment, under the supervision of their physician, received a 1-month non-drug treatment program including cognitive training, detailed recommendations for physical activity, and dietary planning.
Results: After the end of the course of treatment, improvements in the MoCa test were achieved by 22 patients (73%), which made up Group 1.
The possibility of epileptiform activity generation by the thalamocortical neuronal network after focal brain injuries, including traumatic brain injury (TBI), is actively debated. Presumably, posttraumatic spike-wave discharges (SWDs) involve a cortico-thalamocortical neuronal network. Differentiation of posttraumatic and idiopathic (i.
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