Publications by authors named "M A Novaes"
Background: The decline in testosterone levels among older men remains a subject of debate. While some cross-sectional and longitudinal studies have reported a decrease in testosterone with advancing age, others have not observed this trend. In this study, we aimed to evaluate testosterone levels and identify predictors of low testosterone in an age-stratified cohort of men.
View Article and Find Full Text PDFSynchronization is an important phenomenon in a wide variety of systems comprising interacting oscillatory units, whether natural (like neurons, biochemical reactions, and cardiac cells) or artificial (like metronomes, power grids, and Josephson junctions). The Kuramoto model provides a simple description of these systems and has been useful in their mathematical exploration. Here, we investigate this model by combining two common features that have been observed in many systems: External periodic forcing and higher-order interactions among the elements.
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- - The study focuses on isolating and characterizing oviduct fluid extracellular vesicles (coEV) in goats, which are important for events around conception, as they have been previously identified in other mammals but not in caprine species.
- - Two experiments were conducted: one to isolate coEV from individual goats or a pool of three, and the other to analyze coEV during different phases of the estrous cycle (follicular vs. luteal).
- - Findings showed that while the size distribution of coEV was similar regardless of isolation method, those collected during the luteal phase were larger, and the presence of specific proteins indicated they were exosomes with distinct characteristics.
Anticancer therapy often leads to premature ovarian insufficiency (POI) and infertility due to the extreme sensitivity of the ovarian follicle reserve to the effects of chemotherapy. Withanolides are known for their cytotoxic effect on cancer cells and low cytotoxicity on non-malignant or healthy cells. Therefore, this study aimed to investigate the effects of three withanolides derivatives: 27-dehydroxy-24,25-epoxywithaferin A (WT1), 27-dehydroxywithaferin A (WT2), and withaferin A (WTA) on fertility, and the ovarian preantral follicles of young female mice.
View Article and Find Full Text PDFWe generalize the Kuramoto model by interpreting the N variables on the unit circle as eigenvalues of a N-dimensional unitary matrix U in three versions: general unitary, symmetric unitary, and special orthogonal. The time evolution is generated by N^{2} coupled differential equations for the matrix elements of U, and synchronization happens when U evolves into a multiple of the identity. The Ott-Antonsen ansatz is related to the Poisson kernels that are so useful in quantum transport, and we prove it in the case of identical natural frequencies.
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