Publications by authors named "M A Nicolaie"
Article Synopsis
- The study investigates differences in antibody responses to SARS-CoV-2 between children and adults, focusing on various Fc-mediated functions like phagocytosis and natural killer cell activation over a 10-month period.
- Results indicate that children exhibit similar, but potentially more durable, antibody responses, particularly in complement deposition, compared to adults, while natural killer cell activation was notably reduced in both groups.
- Understanding these differences is important for developing tailored vaccination strategies against respiratory viruses, highlighting the need for age-specific insights in vaccine design.
Objective: The present meta-analysis aimed to investigate which are the most efficient psychological and physical interventions for professional caregivers.
Method: The study was realized using information extracted from 28 randomized controlled trials, totaling 2,168 participants, with mean ages between 22.88 and 48.
Article Synopsis
- Young children and older adults are particularly vulnerable to invasive pneumococcal disease (IPD) due to lower levels of protective antibodies against Streptococcus pneumoniae.
- Research measured IgG and IgA antibodies in serum and saliva across different age groups, revealing that younger children have significantly lower antibody levels and avidity compared to adults.
- The findings suggest that repeated exposure to pneumococci through factors like daycare attendance boosts antibody levels, with young children’s low antibody profiles contributing to their susceptibility to IPD and older adults experiencing different influencing factors.
Introduction: Accumulating evidence indicates the importance of T cell immunity in vaccination-induced protection against severe COVID-19 disease, especially against SARS-CoV-2 Variants-of-Concern (VOCs) that more readily escape from recognition by neutralizing antibodies. However, there is limited knowledge on the T cell responses across different age groups and the impact of CMV status after primary and booster vaccination with different vaccine combinations. Moreover, it remains unclear whether age has an effect on the ability of T cells to cross-react against VOCs.
View Article and Find Full Text PDFRespiratory pathogens can cause severe disease and even death, especially in the very young and very old. Studies investigating their prevalence often focus on individuals presenting to healthcare providers with symptoms. However, the design of prevention strategies, e.
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