Publications by authors named "M A Nashat"
Article Synopsis
- Amino-terminal acetylation is a prevalent modification in proteins, influencing around 80% of human proteins, with the NAA10 gene encoding the key enzyme for this process.
- In mice, while NAA10 is not essential due to a backup gene (NAA12), its absence leads to various severe defects and influences developmental outcomes, highlighting significant genetic variability.
- New experiments show that these defects can be affected by both the genetic background of the mice and environmental factors, though some previously reported lethality effects were not replicated in this study.
Article Synopsis
- * Genetic variations in NAA10 exist among humans, while studies show that its paralogous gene in mice can compensate for NAA10 loss, leading to a range of phenotypic defects like small size and skeletal issues.
- * New experiments confirm these defects in mice but highlight that their severity is affected by both genetic background and environmental factors, contrary to previous reports of maternal effect lethality in female mice.
Background: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility.
Methods: One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited.
Article Synopsis
- Beta-thalassemia major is a common chronic anemia in children and adolescents, often leading to heart issues despite normal left ventricular function; detecting early heart problems is vital.
- This study aimed to see if using two-dimensional speckle-tracking echocardiography (2D-STE) could identify subtle heart dysfunction in thalassemic patients before traditional methods showed issues.
- Results showed that thalassemic patients had significantly lower ventricular strains compared to healthy controls, suggesting 2D-STE could be an effective, cost-efficient way to screen for heart problems in patients with restricted access to MRI.
Background: To date, the cytokine profile in children and adolescent with novel coronavirus disease 2019 (COVID-19) has not been reported.
Objectives: We investigated serum levels of a panel of key cytokines in children and adolescent with COVID-19 pneumonia with a primary focus on "cytokine storm" cytokines such as interleukin (IL)-1β, IL-6, IL-17, IL-2, IL-4, IL-10, interferon (IFN-γ), tumor necrosis factor (TNF)-α, and two chemokines interferon-inducible protein-10 (IP-10) and IL-8. We also studied whether these cytokines could be potential markers for illness severity in COVID-19 pneumonia.