Arch Int Pharmacodyn Ther
August 1988
In the motility of sperm, which resembles the automaticity of smooth muscle in some features, calcium plays an important role. Chlorpromazine (CPZ), an inhibitor of calmodulin (CaM), decreases contractile responses of smooth muscle to agonists, alters microsomal calcium movements and inhibits human sperm motility. The involvement of CaM in the contraction of smooth muscle and in sperm motility and its presence in sperm cells have also been established.
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