Why Teens Don't Talk: Understanding the Role of Stigma Within Barriers to Help Seeking.

The stigma of mental illness, among a larger set of barriers to help seeking, has been understudied among teens. These barriers and the sources of support were examined through an online survey with 1,428 U.S.

Replication stress marker phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.

Background: Ovarian cancer treatment includes cytoreductive surgery, platinum-based chemotherapy, and often poly (ADP-ribose) polymerase (PARP) inhibitors. Homologous recombination (HR)-deficiency is a well-established predictor of therapy sensitivity. However, over 50% of HR-proficient tumors also exhibit sensitivity to standard-of-care treatments.

Regional Anesthesia With Pectoral Blocks as a Non-inferior Approach for Mastectomy Analgesia: A Quality Improvement Study.

Introduction Breast cancer is one of the most common female malignancies in the United States and often necessitates surgical interventions that carry a substantial risk of postoperative pain. Pectoral nerve blocks have emerged as a simpler alternative for providing regional perioperative analgesia to the chest wall in breast cancer surgery. This retrospective study evaluated the impact of implementing a novel regional anesthesia protocol centering on the use of pectoral nerve blocks for patients undergoing radical mastectomy at a small regional hospital in Spartanburg, South Carolina.