Publications by authors named "M A Morell"
Article Synopsis
- The study investigates the characteristics and quality of life (QoL) of patients diagnosed with childhood-onset craniopharyngioma, analyzing data from 66 patients treated between 2008 and 2022.
- Most patients were diagnosed at a young age (around 5 years) and faced long-term complications, including significant endocrine issues and visual deficits.
- QoL scores indicated that while patients rated their QoL higher than their parents did, factors like repeated surgeries, hypothalamic involvement, and the use of radiotherapy were found to negatively impact overall QoL.
This study aimed at defining the role of the B cell adaptor protein BANK1 in the appearance of age-associated B cells (ABCs) in 2 SLE mouse models (TLR7.tg6 and imiquimod-induced mice), crossed with Bank1-/- mice. The absence of Bank1 led to a significant reduction in ABC levels, also affecting other B cell populations.
View Article and Find Full Text PDFIntroduction: The assessment of quality of life (QoL) should be one of the main objectives in paediatric clinical trials. Even though researchers, regulators and advocates support the use of patient-reported outcomes (PROs), this has not been fully implemented. The aim of this study is to assess the measurement of QoL and the usage of PROs, palatability assessments and medication diaries in early-phase clinical trials for childhood and adolescent cancer.
View Article and Find Full Text PDFCetaceans have undergone profound sensory adaptations in response to their aquatic environment during evolution. These adaptations are characterised by anatomo-functional changes in the classically defined sensory systems, shaping their neuroanatomy accordingly. This review offers a concise and up-to-date overview of our current understanding of the neuroanatomy associated with cetacean sensory systems.
View Article and Find Full Text PDFVEGF-A-induced changes in distal outflow tract structure and function.
Graefes Arch Clin Exp Ophthalmol
February 2024
Purpose: To investigate changes in distal outflow tract vessels caused by VEGF-A and their impact on outflow.
Methods: We compared VEGF-A perfused porcine anterior segments with and without trabecular meshwork (TM) to control eyes. In the first experiment (n=48), we analyzed live changes of the outflow tract with spectral-domain optical coherence tomography (SD-OCT) over 3 h and reconstructed them in 3D.