The Effect of Thermocycling on the Shear Bond Strength of Flash-free Brackets and Healing Dynamics of Enamel Microcracks: An Study.

Aim: This study evaluates long-term shear bond strength (SBS) and enamel micro cracks (MCs) healing after using adhesive pre-coated brackets (APC).

Materials And Methods: A total of eighty extracted human premolar teeth were randomly divided into four experimental groups ( = 20 per group): Control group: Teeth underwent indentation but no bracket bonding; group II : Teeth were subjected to indentation without exposure to thermocycling; group III: Teeth experienced both indentation and thermocycling; group IV: No indentation was applied to the teeth; groups III and IV were further divided into two subgroups to simulate different clinical timelines: Subgroup A (n = 10): Teeth underwent 5,000 thermocycles, equivalent to six months of clinical use. Subgroup B (n = 10): Teeth were subjected to 10,000 thermocycles, representing 12 months of use.

Antifungal Potentials of Asian Plants: Ethnobotanical Insights and Phytochemical Investigations.

Introduction: Ethnomedicinal plants in Asia offer a promising, low-side-effect alternative to synthetic drugs for treating fungal infections, one of the most widespread communicable diseases caused by pathogenic fungi. Despite being underexplored, the region's rich plant diversity holds the potential for developing effective antifungal drugs. Research is increasingly focused on bioactive compounds from these plants, which show strong antifungal properties and may serve as leads for new drug development.

The sesquiterpene alcohol farnesol mitigates cadmium hepatotoxicity by attenuating oxidative stress and NF-kappaB/NLRP3 inflammasome axis and upregulating PPARgamma in rats.

Farnesol (FAR) is a sesquiterpene alcohol that exists in many fruits and vegetables and possesses promising anti-inflammatory and antioxidant activities. Cadmium (Cd) is an environmental pollutant known for its serious health effects. Liver injury associated with oxidative stress is a hazardous consequence of exposure to Cd.

Focal Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss.

Introduction: Septic arthritis, primarily caused by (), is a severe joint infection that leads to joint and bone damage. lipoproteins (LPPs) bind to Toll-like Receptor 2 (TLR2), inducing arthritis and localized bone loss. Aging affects TLR2 immune response to pathogens.

Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patients.

Background: To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race of origin in a global cohort of patients.

Methods: Retrospective collaborative study of 1426 patients who underwent primary enucleation for retinoblastoma.

Results: Patients were grouped into Caucasians (n = 231, 16%), Asians (n = 841, 59%), Hispanics (n = 226, 16%), Arabs (n = 96, 7%) and Others (Africans, African Americans, Indigenous Australians; n = 32, 2%) cohorts.