Biomarkers.

Background: By 2025, an estimated three-quarters of the global population aged 60 and older will live in Latin American and Caribbean countries (LAC), leading to a rise in age-related conditions. The main goal of the Panama Aging Research Initiative - Health Disparities (PARI-HD) research program is to create a platform for multidisciplinary clinical studies that focus on mental health and its diseases such as age-related cognitive decline. This platform would generate a large amount of clinical, neuropsychological, lifestyle, genetic and biomarker data following standardized research protocols.

Biomarkers.

Background: The prevalence of Alzheimer's disease (AD) is increasing worldwide, particularly in low- to middle-income countries (LMICs). Resource limitations and time constraints in many LMICs make AD screening and diagnosis difficult in the clinical setting. Neurodegenerative biomarkers in human tears may be associated with neurodegenerative diseases, but its potential has yet to be investigated in AD.

Biomarkers.

Background: To date, all computerised perivascular spaces (PVS) quantification methods require case-wise, imaging modality, or study-specific parameter adjustments, and suffer from generalisability problems in clinical settings, and misdetection of other cerebral small vessel disease (CSVD) markers. We propose a deep learning-based PVS detection method to overcome these issues. We compare our proposal on magnetic resonance imaging data of CSVD participants against the performance of the Frangi filter.

Biomarkers.

Background: We are conducting a biomarker-based study to describe the demographic and biomarker profiles of Panamanians. The objective of this report is to present the main findings on CSF, genetic and serological biomarkers' distribution and their association with cognition in a cohort of elderly people in Panama.

Method: Informed consent was applied to all participants, demographic data, medical history, and neuropsychological and functional status were collected, and non-fasting blood samples were obtained.