Publications by authors named "M A Manu"
The systematic review summarizes the current evidence on the efficacy and safety of iron replacement in patients with pulmonary hypertension (PH). A systematic literature search was conducted in electronic databases like PubMed, Scopus, Web of Science, and Embase up to April 2024. Eligible studies investigating iron replacement therapy in pulmonary hypertension patients were included in the review.
View Article and Find Full Text PDFEfficacy of probiotics as adjuvant therapy in bronchial asthma: a systematic review and meta-analysis.
Allergy Asthma Clin Immunol
November 2024
Background: Asthma is a chronic, heterogeneous disease characterized by airway inflammation. Asthma exacerbations significantly increase the disease burden, necessitating new therapeutic approaches. Emerging evidence suggests probiotics, through the gut-lung axis, may benefit asthma management by modulating immune responses and reducing inflammation.
View Article and Find Full Text PDFMetformin use and its association with various outcomes in COVID-19 patients with diabetes mellitus: a retrospective cohort study in a tertiary care facility.
Ann Med
December 2024
Background: Evidence shows that diabetes raises the probability of contracting COVID-19 and associated complications. We hypothesize that metformin, being pleiotropic, may improve COVID-19 in diabetics.
Methods: A retrospective cohort study was conducted with 421 COVID-19 patients with diabetes, hospitalized between 1st April 2020 and 31st March 2022 in a tertiary-care hospital.
Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disease that involves the immune system attacking the nervous system, and there's a key difference in gut bacteria between its progressive and non-progressive forms.
- Researchers found a specific cluster of the gut bacteria "Tyzzerella nexilis" that is more abundant in progressive MS patients, which has unique genetic features.
- This particular strain of T. nexilis carries mobile genetic elements that could enhance its pathogenic potential, making mice more susceptible to MS-like symptoms when exposed to it, suggesting it may play a role in disease progression.