Publications by authors named "M A Maniati"
Background: Atherosclerosis is an arterial blood vessel disease that begins and progresses by turning macrophages into foam cells. Uptake of oxidized low-density lipoprotein (ox-LDL), cholesterol esterification and cholesterol efflux are the most important factors in the formation of foam cells and play an important role in atherosclerosis.
Methods: The present study is based on the data obtained from the PubMed database (1961-2024) using the MeSH search terms "Atherosclerosis", "Macrophages" and "Foam cells".
Article Synopsis
- Depression and anxiety are common issues for patients with idiopathic pulmonary fibrosis (IPF), negatively impacting their quality of life, especially during the COVID-19 pandemic.
- A study aimed to evaluate how COVID-19 vaccination affects these mental health issues in IPF patients, using the Hospital Anxiety and Depression Scale (HADS) to measure changes before and after vaccination.
- Results showed a significant improvement in both anxiety and depression scores one month after vaccination, indicating that the vaccine may have beneficial effects on mental health for IPF patients, regardless of factors like age or previous mental health history.
Background: Burnout is a work-related syndrome that can affect physicians' performance. Empathy is one of the clinical competencies in whose formation many factors play a role. Empathy and burnout are important topics of research in medical sciences, and both are related to the communication between the patient and the physician.
View Article and Find Full Text PDF5-EPIFAT trial protocol: a multi-center, randomized, placebo-controlled trial of the efficacy of pharmacotherapy for fatigue using methylphenidate, bupropion, ginseng, and amantadine in advanced cancer patients on active treatment.
Trials
April 2024
Background: Cancer-related fatigue (CRF) is still undertreated in most patients, as evidence for pharmacological treatments is limited and conflicting. Also, the efficacy of the pharmacological agents relative to each other is still unclear. Therefore, medications that may potentially contribute to improving CRF will be investigated in this head-to-head trial.
View Article and Find Full Text PDFIntroduction: Pathogenic variants in parkin (PRKN gene) are the second most prevalent known monogenic cause of Parkinson's disease (PD). How monoallelic or biallelic pathogenic variants in the PRKN gene may affect its transcription in patient-derived biological material has not been systematically studied.
Methods: PRKN mRNA expression levels were measured with real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs).