Publications by authors named "M A Maloy"
Article Synopsis
- Myeloablative T cell depleted hematopoietic cell transplantation (HCT) leads to lower rates of acute and chronic graft versus host disease (GVHD) and can allow patients to respond to vaccinations post-transplant.
- A study of 251 patients showed that 30.7% were vaccinated, with varying success rates in generating protective antibodies for diseases like hepatitis and pneumococcus.
- Increased counts of specific T and B cell subsets may help predict which patients will have a better response to vaccinations after CD34-selected HCT, despite no significant differences noted for those who received rituximab treatment.
The Web-based One Year Survival Outcomes Calculator developed by the Center for International Blood and Marrow Transplant Research (CIBMTR) applies large-scale registry data to generate individualized estimates of overall survival (OS) probability 1 year after first allogeneic hematopoietic cell transplant (HCT) and can therefore provide a data-driven foundation for personalized patient counseling. We assessed the calibration of the CIBMTR One Year Survival Outcomes Calculator when applied to retrospective data among adult recipients of first allogeneic HCT for acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS) with peripheral blood stem cell transplant (PBSCT) from a 7/8- or 8/8-matched donor from 2000 through 2015 at a single center. Predicted 1 year OS was estimated for each patient using the CIBMTR Calculator.
View Article and Find Full Text PDFDiscerning the effect of pharmacological exposures on intestinal bacterial communities in cancer patients is challenging. Here, we deconvoluted the relationship between drug exposures and changes in microbial composition by developing and applying a new computational method, PARADIGM (parameters associated with dynamics of gut microbiota), to a large set of longitudinal fecal microbiome profiles with detailed medication-administration records from patients undergoing allogeneic hematopoietic cell transplantation. We observed that several non-antibiotic drugs, including laxatives, antiemetics, and opioids, are associated with increased Enterococcus relative abundance and decreased alpha diversity.
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- Cytomegalovirus (CMV) infection leads to the growth of a specific type of natural killer (NK) cell, known as NKG2C+ NK cells, but the reasons behind this development are still unclear.
- * Researchers studied blood samples from 119 patients who underwent allogeneic hematopoietic cell transplantation (HCT) to observe how different types of grafts affect immune cell recovery, especially in the context of CMV reactivation.
- * Findings showed that a significant number of patients with CMV reactivation (92%) had NKG2C+ NK cells after receiving T-cell-depleted (TCD) grafts, highlighting a potential link between the recovery of T cells and the expansion of these NK
Older patients with hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplant (allo-HCT). However, older patients often have increased comorbidities and thus may require an increased level of post-transplant care. These factors can contribute to increased caregiver distress, which has been associated with worsened health outcomes for caregivers and patients.
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