A systematic review of approaches to assess fish health responses to anthropogenic threats in freshwater ecosystems.

Anthropogenic threats such as water infrastructure, land-use changes, overexploitation of fishes and other biological resources, invasive species and climate change present formidable challenges to freshwater biodiversity. Historically, management of fish and fishery species has largely been based on studies of population- and community-level dynamics; however, the emerging field of conservation physiology promotes the assessment of individual fish health as a key management tool. Fish health is highly sensitive to environmental disturbances and is also a fundamental driver of fitness, with implications for population dynamics such as recruitment and resilience.

Inbred SJL mice recapitulate human resistance to infection due to differential immune activation.

Cryptococcosis studies often utilize the common C57BL/6J mouse model. Unfortunately, infection in these mice fails to replicate the basic course of human disease, particularly hampering immunological studies. This work demonstrates that SJL/J mice can recapitulate human infection better than other mouse strains.

Improving documentation of treatment escalation decisions in acute care.

The aim of this project was to improve the documentation of treatment escalation decisions at a district general hospital in southwest England. A pilot "Ceiling of Treatment" proforma was trialled on the care of the elderly wards at the Royal United Hospital (RUH), Bath. Successive PDSA cycles enabled revision of the proforma for use across the Trust.

High-energy response of passive dosemeters in use at LANL.

The high-energy neutron response of three passive dosemeters in use at the Los Alamos National Laboratory (LANL) has been investigated using metrology-grade fields. The dosemeters include the LANL Model 8823 TLD badge and the LANL PN3 track etch device. Both are dosemeters of record at LANL.