Publications by authors named "M A M Lemmens"
Photon-counting detector computed tomography (PCD-CT) has emerged as a revolutionary technology in CT imaging. PCD-CT offers significant advancements over conventional energy-integrating detector CT, including increased spatial resolution, artefact reduction and inherent spectral imaging capabilities. In cardiac imaging, PCD-CT can offer a more accurate assessment of coronary artery disease, plaque characterisation and the in-stent lumen.
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- Colonoscopy surveillance for colorectal cancer (CRC) can be burdensome for patients, and stool tests might help reduce the need for colonoscopies by identifying individuals at higher risk.
- This study involved 3453 participants aged 50-75 who completed multiple stool tests and colonoscopies to assess the accuracy of these methods for detecting advanced neoplasia.
- Results indicated that stool-based strategies could effectively reduce colonoscopy frequency by 15%-41% while being safer and more cost-effective, particularly with fecal immunochemical tests (FITs), although multitarget stool DNA testing was found to be more expensive.
Article Synopsis
- Colonoscopy surveillance for individuals with Lynch syndrome is challenging, and colorectal cancers can still occur despite regular screenings.
- A study evaluated the efficacy of fecal immunochemical tests (FIT) to determine the best intervals for colonoscopy by measuring specific thresholds of hemoglobin in stool samples.
- Results indicated that using a lower FIT threshold (2.5 μg Hb/g) increased the detection rate of relevant neoplasia, with even better specificity seen at a threshold of 4.1 μg Hb/g, suggesting that FIT could potentially allow many Lynch syndrome patients to delay unnecessary colonoscopies while still effectively identifying those at risk for advanced neoplasia.
Article Synopsis
- - The study focused on the safety concerns of residual undifferentiated pluripotent stem cells (PSCs) in cell therapy products (CTPs), which could lead to tumor formation in clinical applications.
- - Researchers tested a droplet digital PCR (ddPCR) method to detect leftover induced pluripotent stem cells (iPSCs) in cardiomyocyte samples by varying their concentrations and measuring specific iPSC markers for accuracy.
- - Findings indicated that the RT-ddPCR assay effectively identifies iPSC impurities in CTPs, with variability primarily arising from how iPSCs were added to samples, showcasing the method's potential for ensuring safety in PSC-derived therapies.