[Cerebral vascular diseases and oxidative stress].

Cerebral vascular diseases are a strategically important medical-social and economic problem of the present. An analysis of the basic pathogenetic mechanisms of development of this pathology will allow to solve the questions of complex adequate pathogenetic therapy and lower relative density of menacing complications of these diseases: death rate and debilitation.

[Oxidative stress in the pathogenesis of stroke].

Free radical oxidation of lipids and proteins is the universal process constantly proceeding in cells, tissues and organs during the lifetime of organism. In certain conditions, this process can be a basis of pathology, one of the mechanisms of disease development, including stroke.

Oxidant stress in the pathogenesis of multiple sclerosis.

We report here an analysis of measures of the intensification of lipid peroxidation and the state of the non-enzymatic and enzymatic components of the antioxidant defense system in different clinical forms and stages of multiple sclerosis. The data obtained support the role of oxidant stress in the development of the pathological process in multiple sclerosis.

[Oxidant stress in the pathogenesis of multiple sclerosis].

The problem of pathogenesis of multiple sclerosis is of great importance in modern neurology and its solution allows to determine a pathogenetic approach to treatment of this severe disease. Parameters of intensification of lipid peroxidation and indices of the state of enzymatic and non-enzymatic patterns in antioxidant defense system in different clinical forms and at different stages of MS course have been analyzed. The data obtained confirm the presence of oxidant stress in the development of pathological process in MS.