Publications by authors named "M A Luque-Fernandez"

Background: Individual and tumour factors only explain part of observed inequalities in colorectal cancer survival in England. This study aims to investigate inequalities in treatment in patients with colorectal cancer.

Methods: All patients diagnosed with colorectal cancer in England between 2012 and 2016 were followed up from the date of diagnosis (state 1), to treatment (state 2), death (state 3) or censored at 1 year after the diagnosis.

View Article and Find Full Text PDF

Purpose: The targeted maximum likelihood estimation (TMLE) statistical data analysis framework integrates machine learning, statistical theory, and statistical inference to provide a least biased, efficient, and robust strategy for estimation and inference of a variety of statistical and causal parameters. We describe and evaluate the epidemiological applications that have benefited from recent methodological developments.

Methods: We conducted a systematic literature review in PubMed for articles that applied any form of TMLE in observational studies.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the potential of plasma glycated CD59 (pGCD59) as a biomarker to predict postpartum glucose intolerance in women who had gestational diabetes.
  • Postpartum pGCD59 levels were significantly higher in women with glucose intolerance compared to those with normal levels, and it showed good predictive ability with an area under the curve (AUC) of 0.80.
  • However, while pGCD59 may help identify women who do not need traditional glucose intolerance screening, fasting plasma glucose tests demonstrated even better diagnostic accuracy.
View Article and Find Full Text PDF

Aim: Even though most pregnancies are uneventful, occasionally complications do occur. Gestational diabetes is linked to an increased risk of adverse pregnancy outcomes. Early identification of women at risk of experiencing adverse outcomes, ideally through a single blood test, would facilitate early intervention.

View Article and Find Full Text PDF