Publications by authors named "M A Losi"
Background: Hereditary transthyretin (ATTRv) amyloidosis is rare, autosomal dominant disease with a fatal outcome if left untreated. Early stages detection is crucial for intervention. We aimed identifying early indexes of cardiac involvement and their eventual correlation with neurological indexes, in pre-symptomatic subjects with TTR gene mutation.
View Article and Find Full Text PDFIn patients with severe left ventricle hypertrophy and aortic stenosis, the presence of intraventricular gradient should always be investigated. Its prompt recognition enables a precise diagnosis and safe treatment of both conditions. We report 2 cases demonstrating a successful and novel approach to this clinical situation.
View Article and Find Full Text PDFArticle Synopsis
- Orthostatic hypotension (OH) is a common issue linked to autonomic dysfunction but can arise from other causes, highlighting the complexity of its mechanisms.* -
- A case of an 88-year-old woman revealed that her recurrent fainting episodes while standing were due to OH linked to mid-left ventricular obstruction, which was identified through echocardiography.* -
- Treatment that included stopping diuretics and administering fluids and beta-blockers successfully resolved her OH, emphasizing the need to explore various treatments beyond standard practices for elderly patients.*
Prolonged Time-to-antihypertensive Therapy Worsens Organ Damage and Blood Pressure Control in Arterial Hypertension.
High Blood Press Cardiovasc Prev
November 2024
Introduction: Delay in arterial hypertension (AH) diagnosis and late therapy initiation may affect progression towards hypertensive-mediated organ damage (HMOD) and blood pressure (BP) control.
Aim: We aimed to assess the impact of time-to-therapy on BP control and HMOD in patients receiving AH diagnosis.
Methods: We analysed data from the Campania Salute Network, a prospective registry of hypertensive patients (NCT02211365).
Article Synopsis
- Women generally have a lower risk of cardiovascular disease compared to men, but it's unclear how hypertension-related organ damage affects this difference.
- A study assessed whether carotid plaque influences the risk of cardiovascular events in young patients with treated hypertension, finding that women without carotid plaque had a significantly lower risk than men.
- However, when carotid plaque was present, the cardiovascular risk for women was similar to that of men, indicating that carotid plaque neutralizes the protective effect in women.