Publications by authors named "M A Lopez-Martinez"
Background: Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. While a growing number of biomarkers can be measured in porcine oral fluid, the use of these analytes to compare commercial herds in veterinary practice is still limited.
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- Recent increases in meat production have harmful effects on the environment, highlighting the need for better use of meat by-products.
- The study focuses on improving enzymatic hydrolysis of pork liver using ultrasound and thermal pretreatments to enhance the production of beneficial bioactive peptides and flavors.
- Results show that ultrasound treatment significantly boosts the release of umami and taste-related amino acids, along with increasing antioxidant activity in pork liver hydrolyzates, suggesting its potential as a functional ingredient.
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
J Clin Med
November 2024
Article Synopsis
- Recent research on late-life dementia highlights both neurodegenerative and vascular conditions contributing to the varied symptoms in patients, utilizing the Vallecas Alzheimer's Reina Sofía (VARS) cohort with over 550 participants and associated brain donations.
- The study focused on 167 patients, primarily older women (79%) with an average age of 88, and found a significant presence of the ApoE-e4 gene variant (43%).
- The main findings revealed that 79.6% had Alzheimer's disease, with a high prevalence of other conditions like vascular dementia and Lewy body dementia, and over 71.1% of the patients showed multiple neuropathological findings, indicating the complexity of dementia in this cohort.
(1) Reduced glutathione (GSH) is considered the first line of antioxidant defense. During oxidative stress, it is oxidized to glutathione disulphide (GSSG). (2) A simple and quick spectrophotometric method based on sodium borohydride (NaBH) as a reductant to measure the total and reduced GSH in porcine saliva was analytically validated and evaluated in two situations in this species: (a) in a physiological situation, involving sows during the late lactation and post-weaning periods, and (b) in a situation of sepsis in pigs experimentally induced by LPS administration.
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- Semaglutide, a drug for type 2 diabetes, shows promise in reducing albuminuria and slowing kidney disease progression in patients with chronic kidney disease (CKD) in a double-blind clinical trial.
- The study involved 101 participants, comparing those receiving 2.4 mg of semaglutide weekly to a placebo, with a focus on changes in urine albumin-to-creatinine ratio after 24 weeks.
- Results indicated a significant 52.1% reduction in albuminuria for the semaglutide group, although gastrointestinal side effects were more common compared to the placebo group.