Significant attenuation of fully automated thrombin generation in newly diagnosed multiple myeloma patients after induction therapy.

Nearly 10% of newly diagnosed multiple myeloma (NDMM) patients develop a venous thromboembolism (VTE) episode during their disease course, despite current thromboprophylaxis strategies. Changes in hypercoagulability in these patients after treatment have been analyzed using the thrombin generation (TG) assay, the results being discrepant, probably due to the use of semi-automated techniques. This study aims to assess changes in TG measured by a fully automated analyzer.

The impact of affective and cognitive empathy on stress in medical students.

Objective: To analyze the relationship between empathy and its domains (i.e., affective and cognitive) and stress in medical students.

Exploring mercury and selenium dynamics in Amazonian human populations: Insights from urine, blood, and plasma analyses.

The Amazonian riverside population is one of the most impacted by mercury, interestingly, with distinct selenium values in blood, generally among the highest worldwide. The interaction between Hg and Se remains to be thoroughly investigated and could provide insights into the fate of these elements and the potential for selenium-mediated detoxification. The current study explores the levels of both elements, determined by inductively coupled plasma mass spectrometry (ICP-MS), in blood, plasma, and urine, of 1089 adult individuals from communities of Tapajós and Amazon River.

Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting-A Comprehensive Review of Its Unusual Health Benefits.

Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment for several diseases mainly related to the immune system, inflammation, and oxidative stress. Moreover, a melatonin-rich diet is linked to several health benefits, such as regulation of circadian rhythm, regulation of the immunological system, epilepsy control, delaying the aging process, and diminishing hormones related to cancer.

NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction.

Chronic lung allograft dysfunction (CLAD) substantially limits long-term survival following lung transplantation. To identify potential targets for CLAD prevention, T cells from explanted CLAD lungs and lung-draining lymph nodes, as well as diseased and nondiseased controls were isolated and single-cell RNA sequencing and TCR sequencing were performed. TCR sequencing revealed a clonally expanded population of CD8+ tissue-resident memory T cells (TRMs) with high cytotoxic potential, including upregulation of KLRK1, encoding the co-receptor NKG2D.