Publications by authors named "M A Lia"
Background: Numerous studies have identified typical risk factors for surgical site infections (SSI) and fascial dehiscence (FD), but patients with gynecological cancer are often excluded. This study aimed to assess the key risk factors for SSI and FD in gynecological oncological patients undergoing median laparotomy.
Methods: We conducted a retrospective cohort study of patients who underwent median laparotomy for gynecological cancer between January 2017 and December 2020.
Introduction: Optimal counseling of women for vaginal breech birth requires consideration of both established and emerging risk factors for adverse perinatal outcomes. Currently, rising prevalences of maternal obesity and impaired glucose tolerance challenge obstetric care. We aimed to investigate the effects of these parameters on the outcome of vaginal breech birth to improve counseling practices.
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- The study aims to create prediction models for intrapartum cesarean sections during vaginal breech births, focusing on nulliparous (first-time mothers) and multiparous (previously giving birth) women.
- Two prediction models were developed for each group, with the nulliparous model having an AUC (Area Under Curve) of 0.67 and the multiparous model showing better performance at 0.77, indicating higher accuracy.
- Key risk factors identified include epidural analgesia, maternal height, birth weight, and abdominal circumference, with a significant finding that certain factors only influence cesarean outcomes when birth weights exceed 3.8 kg or abdominal circumference is above 34 cm.
Article Synopsis
- Low molecular weight heparins (LMWH) are used in pregnancy to prevent or treat thromboembolic events and may have protective effects against preeclampsia, although their use in this context is debated.
- Recent research shows that LMWH can reduce pregnancy loss and inflammation-related activation of the NLRP3 inflammasome in trophoblasts, which are crucial for a healthy pregnancy.
- The mechanism involves LMWH activating the heparin-binding epidermal growth factor (HBEGF) pathway, which prevents inflammasome activation and could provide a rationale for using LMWH in managing preeclampsia.
: Placenta accreta spectrum (PAS) can be the cause of major morbidity and its optimal management is still controversial. The aim of this study was to compare the traditional one-step surgery with a two-step surgical approach in which the placenta is left in situ and the second final operation is delayed to minimise blood loss. : We conducted a single-centre retrospective cohort study including all patients managed for PAS between 2007 and 2023.
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