Publications by authors named "M A Lebot"
Background: Monitoring the ecological status of coastal ecosystems is essential to track the consequences of anthropogenic pressures and assess conservation actions. Monitoring requires periodic measurements collected in situ, replicated over large areas and able to capture their spatial distribution over time. This means developing tools and protocols that are cost-effective and provide consistent and high-quality data, which is a major challenge.
View Article and Find Full Text PDFElevation of nonfasting triglyceride (TG) levels above 1.8 g/L (2 mmol/L) is associated with increased risk of cardiovascular diseases. Exacerbated postprandial hypertriglyceridemia (PP-HTG) and metabolic context both modulate the overall efficacy of the reverse cholesterol transport (RCT) pathway, but the specific contribution of exaggerated PP-HTG on RCT efficacy remains indeterminate.
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- DARPP-32 (encoded by the PPP1R1B gene) is a protein that inhibits certain enzymes and is present in various cells, but its specific role in breast cancer is still being studied.
- Research involving two cohorts of breast cancer patients showed that lower levels of DARPP-32 expression are linked to shorter survival times, indicating its potential as a prognostic marker.
- The findings suggest that DARPP-32 expression, particularly in estrogen receptor-positive breast cancer, could help predict patient outcomes and may have clinical relevance in treatment decision-making.
Article Synopsis
- G protein-coupled estrogen receptor 1 (GPER), also known as GPR30, is being studied for its influence on breast cancer development, particularly through non-genomic signaling activated by estrogen.
- Research on 1,245 breast cancer patients reveals that low GPER protein expression is linked to aggressive cancer features and poorer survival outcomes.
- Analysis of the METABRIC cohort shows that low GPER mRNA levels correlate with adverse survival, and artificial neural networks identify related genes like notch-4 and jagged-1, emphasizing GPER's potential as a prognostic marker in breast cancer.
Context: QT interval duration is longer in women than in men. Sex steroid hormones have inconsistently been suggested to explain this difference. The implication of gonadotropins has never been studied.
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