Publications by authors named "M A L Pelsers"
Background/objectives: Increased risk of type 2 diabetes mellitus (T2DM) is linked to impaired muscle mitochondrial function and reduced mitochondrial DNA copy number (mtDNA). However, studies have failed to control for habitual physical activity levels, which directly influences both mtDNA copy number and insulin sensitivity. We, therefore, examined whether physical conditioning status (maximal oxygen uptake, V̇O) was associated with skeletal muscle mitochondrial volume and mtDNA, and was predictive of T2DM in overweight, middle-aged men.
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- The glycoprotein CD36, found on the surface of intestinal cells, plays a role in the metabolism of long chain fatty acids (LCFAs) and affects chylomicron production, with its deficiency linked to reduced production through unclear mechanisms.
- Research shows that deleting the CD36 gene in mice does not hinder the uptake or processing of LCFAs in the intestine even after a fatty meal, but CD36 levels drop significantly when lipids are consumed.
- The findings indicate that CD36 is important for lipid-triggered signaling pathways and the synthesis of chylomicrons, suggesting it could be targeted for therapies aimed at lowering post-meal triglyceride levels and reducing cardiovascular disease risk.
Background: There is a need for biomarkers in accessible matrices, such as blood, for the diagnosis of neurodegenerative diseases. The aim of this study was to measure the serum levels of brain-type fatty acid-binding protein (FABP) and heart-type FABP in patients with dementia-involving diseases.
Methods: Brain- and heart-type FABP were measured in serum samples from patients with either Alzheimer's disease (AD) (n = 31), Parkinson's disease (PD, n = 43), or other cognitive disorders (OCD, n = 42) and in 52 healthy controls.
Background: Protein distribution profiles along the human intestinal tract of transporters involved in the absorption of cholesterol and long-chain fatty acids (LCFA) have been scarcely evaluated.
Methodology/principal Findings: In post-mortem samples from 11 subjects, intestinal transporter distribution profiles were determined via Western Blot. Differences in transporter protein levels were statistically tested using ANOVA and Tukey's Post Hoc comparisons.
Objective: The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration.
Study Design: One hundred twenty appropriate-for-gestational-age and 81 IUGR fetuses were classified in stages 1/2/3 according umbilical artery present/absent/reversed end-diastolic blood flow, respectively. Cardiac function was assessed by modified-myocardial performance index, early-to-late diastolic filling ratios, cardiac output, and cord blood B-type natriuretic peptide; myocardial cell damage was assessed by heart fatty acid-binding protein, troponin-I, and high-sensitivity C-reactive protein.