Publications by authors named "M A Krasilnikov"
Enveloped viruses, such as flaviviruses and coronaviruses, are pathogens of significant medical concern that cause severe infections in humans. Some photosensitizers are known to possess virucidal activity against enveloped viruses, targeting their lipid bilayer. Here we report a series of halogenated difluoroboron-dipyrromethene (BODIPYs) photosensitizers with strong virus-inactivating activity.
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- Resistance to hormonal and targeted therapies in breast cancer is influenced by epigenetic alterations, particularly through DNA methylation changes linked to DNMT3A suppression.
- The study investigates the role of NR6A1 as a regulatory factor involved in this suppression, finding that its downregulation is critical for developing resistance.
- The research reveals that changes in cell signaling pathways and the activation of Snail, a key regulator, are associated with resistance, suggesting that the NR6A1/DNMT3A axis could help inform future breast cancer treatment strategies.
The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines as targets where senescence is induced in vitro, which does not necessarily reflect the identity and function of pathogenic senescent cells in vivo. Here, we developed a new pipeline leveraging a fluorescent murine reporter that allows for isolation and quantification of p16Ink4a+ cells in diseased tissues.
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- The study focuses on the molecular mechanism of gausemycins, which are a class of antibiotics, and details the isolation of new variants named gausemycins C, D, E, and F.
- It was found that gausemycins A and B exhibit antimicrobial properties that depend on calcium concentrations, requiring more calcium than daptomycin but less than other antibiotics like malacidine.
- The research confirmed that gausemycins affect bacterial membranes by forming pores, with the ability to do so influenced by the composition of the lipid membranes and calcium levels, as suggested by NMR studies on gausemycin B.
Combining chemotherapy and hormone therapy is a prevalent approach in breast cancer treatment. While the cytotoxic impact of numerous chemotherapy drugs stems from DNA damage, the exact role of these DNA alterations in modulating estrogen receptor α (ERα) machinery remains elusive. The present study aimed to analyze the impact of DNA damage agents on ERα signaling in breast cancer cells and assess the signaling pathways mediating the influence of DNA damage drugs on the ERα machinery.
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