[Early changes in template DNA structure following glucocorticoid injection].

The structure of chromatin is changed at early stages of glucocorticoid hormone interaction with rat hepatocytes. These changes consist in: a) increase of actidine orange binding in rate liver nuclei after injection of the hormone; b) decrease of the number of sites in chromatin which are sensitive to nuclease S1; c) inhibition of the nuclei capacity for DNA synthesis in the presence of E. coli DNA polymerase and d) increase of molecular weight of DNA fragments.