Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70.

Cryptorchidism, the absence of one or both testicles in the scrotum, is the most common anomaly of genitourinary tract in males. The pathogenesis of undescended testes is unknown however the role of inflammation, tissue remodeling and oxidative stress is postulated. The aim of this study was to explore the role of HSP-70, MMP-3, MMP-17 and IL-8 in possible pathogenic pathways connected with cryptorchidism.

Opinion of Polish doctors on the use of futile therapy.

The discontinuation of futile therapy is increasingly discussed in Polish clinical practice. Given the need to ensure patient well-being, it is essential to consider whether all clinical options resulting from medical progress should be used for every patient and on what grounds decisions to limit therapy should be based. The aim of our study was to determine the opinions of Polish medical doctors on this topic.

Change in quality of life in medical students across graduation: results of POLLEK study.

Objectives: Medical students experience numerous demands during the education process, which determine their quality of life (QoL). In particular, the first years of medical studies are a challenge for students. This paper aims to identify and evaluate the quality of life with simultaneous assessment of their determinants in Polish medical students in Poland during longitudinal observation.

Interexaminer agreement of gonioscopy examinations in dogs using the European College of Veterinary Ophthalmologists Hereditary Eye Diseases grading scheme.

Objective: Prospective observational study with preregistered study protocol to assess interexaminer agreement using the 2022 European College of Veterinary Ophthalmologists Hereditary Eye Disease (ECVO-HED) gonioscopy grading scheme.

Animals Studied: Sixty client-owned dogs presented for gonioscopy as part of the required certification process prior to breeding.

Procedure: Two ECVO diplomates with comparable clinical experience performed gonioscopy with a Koeppe gonioscopy lens and slit-lamp biomicroscope at 10x magnification on all eyes in a randomized fashion.

Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors.

Background: Cerebral microbleeds (CMBs) are a possible sequela in human brain tumor patients treated with radiation therapy (RT). No such association is reported in dogs.

Objectives: To investigate whether CMBs occur in dogs after radiotherapy, and if there is an association between number and dose, and an increase over time.