β-Cyclodextrin/Zn-Fe layered double hydroxides/graphitic carbon nitride nanomaterials based potentiometric sensor for paroxetine determination in environmental water samples.

Developing targeted and sensitive analytical techniques for drug monitoring in different specimens are of utmost importance. Herein, a first attempt was made for the determination of paroxetine (Prx) in environmental water samples using a novel, sensitive, selective, stable, accurate and eco-friendly potentiometric sensor based on Zn-Fe layered double hydroxides/graphitic carbon nitride (Zn-Fe LDH/g-CN) nanomaterials with β-cyclodextrin (β-CD) as the sensing ionophore and dibutyl phthalate (DBP) as the plasticizer. The prepared nanomaterial was characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM).

Hyphenating sustainability with chemometrics in chromatographic analysis of COVID combo therapy, nirmatrelvir and Molnupiravir, in presence of their overlapping degradation products; blue-green dual evaluation tools.

Our manuscript managed to hyphenate the novelty and sustainability in one method. A novel combination of molnupiravir (MNP) and nirmatrelvir (NTV) was found to be a potential symbiotic therapy against SARS-CoV-2. Yet, there is no analytical method published for either determination or stability investigation of this combination simultaneously.

Bioanalytical HPLC method with fluorescence detector for determination of Entresto™ when co-administered with ibuprofen and fexofenadine: a pharmacokinetic study.

Entresto™ (LCZ696) has been approved globally for heart failure management. However, its lifelong use alongside over-the-counter (OTC) drugs like ibuprofen (IBU) and fexofenadine (FEX) necessitates an in-depth investigation of potential pharmacokinetic interactions, as they share the same metabolic and elimination pathways. This study aimed to develop a bioanalytical HPLC method with a fluorescence detector (FLD) to quantify LCZ696 analytes (valsartan, VAL; sacubitril, SAC; and sacubitril active metabolite, LBQ657) in rat plasma.