Publications by authors named "M A Kislov"
Article Synopsis
- The study aimed to investigate lung tissue changes in rats after administering baclofen, focusing on the expression of genes related to apoptosis (Bax and Bcl-2) in different lung cell types.
- Twenty Wistar rats were divided into four groups, with varying observation times after receiving baclofen, to assess the corresponding histological and gene expression effects.
- Results showed significant lung damage, including vascular issues and emphysema, peaking at 24 hours, with varying levels of Bax and Bcl-2 expression that indicated a dynamic response to baclofen administration.
Objective: To reveal pathological lung changes in baclofen poisoning and to assess their dynamics.
Material And Methods: The experiment included 20 mature (at age 20 weeks) male rats of Wistar line weighing 290-350 gr. The animals were divided into 3 study groups (5 rats in each) depending on experiment's duration after 85 mg/kg baclofen administration: 3, 4.
The effect of the toxic dose of the muscle relaxant baclofen on the parameters of the cardiovascular and respiratory systems was studied in adult male Wistar rats (n=20). Systolic and diastolic BP, HR, and respiratory rate were measured; histological changes in the lungs 3, 4.5, and 24 h after drug administration.
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