Natural Products in Precision Cryptococcal Meningitis: Phytochemical Screening of Glycyrrhiza glabra Plant against Cryptococcus neoformans Farnesyltransferase (FTase).

Cryptococcus neoformans, the most opportunistic fungal pathogen, causes cryptococcal meningitis. Based on molecular docking and ADME/toxicity analysis, the top two lead compounds selected from a screening of 5,807 phytochemical compounds from 29 medicinal plants were CID_8299 and CID_71346280, with docking scores of -5.786 and -6.

Ergonomics in Laparoscopic Box Training and Virtual Reality (VR) Simulations: A Systematic Review.

Laparoscopic surgery has now become the gold standard in managing most surgical cases. Despite its advantages, working hours and in-theatre training restrictions have prompted trainees to explore alternatives like virtual reality (VR) simulations and box training. Furthermore, given the increased frequency of minimally invasive surgery and the prevalence of musculoskeletal issues among surgeons, there's a growing effort to optimize ergonomics.

AqUavplant Dataset: A High-Resolution Aquatic Plant Classification and Segmentation Image Dataset Using UAV.

Aquatic vegetation species are declining gradually, posing a threat to the stability of aquatic ecosystems. The decline can be controlled with proper monitoring and mapping of the species for effective conservation and management. The Unmanned Ariel Vehicle (UAV) aka Drone can be deployed to comprehensively capture large area of water bodies for effective mapping and monitoring.

The Misclassification of Depression and Anxiety Disorders in the Multiple Sclerosis Prodrome: A Probabilistic Bias Analysis.

Background: Studies suggest that depression/anxiety form part of the multiple sclerosis (MS) prodrome. However, several biases have not been addressed. We re-examined this association after correcting for: (i) misclassification of individuals not seeking healthcare, (ii) differential surveillance of depression/anxiety in the health system, and (iii) misclassified person-time from using the date of the first MS-related diagnostic claim (i.

Premature hair graying: a multifaceted phenomenon.

Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments. The review examines the roles of genetics, oxidative stress, and lifestyle factors such as smoking and diet in premature graying.