Predicting Multijoint Maximal Eccentric and Concentric Strength With Force-Velocity Jump Mechanics in Collegiate Athletes.

Purpose: Maximal muscle strength is often assessed with single-joint or repetition-maximum testing. The purpose of this study was to evaluate the reliability of countermovement-jump (CMJ) velocity-load testing and assess the relationship between CMJ velocity-load kinetics and concentric-isometric-eccentric multijoint leg-extension strength tested on a robotic servomotor leg press in trained athletes.

Methods: University athletes (N = 203; 52% female) completed 3 concentric, isometric, and eccentric maximum voluntary leg-extension contractions on the robotic leg press, followed by CMJ velocity-load testing with an additional external load of 0% (CMJBW), 30% (CMJ30), and 60% (CMJ60) of body mass.

Erroneous Classification and Coding as a Limitation for Big Data Analyses: Causes and Impacts Illustrated by the Diagnosis of Clavicle Injuries.

: Clavicle injuries are common and seem to be frequently subject to diagnostic misclassification. The accurate identification of clavicle fractures is essential, particularly for registry and Big Data analyses. This study aims to assess the frequency of diagnostic errors in clavicle injury classifications.

Return to On-Snow Performance in Ski Racing After Anterior Cruciate Ligament Reconstruction.

Background: The individual variation in on-snow performance outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR) in elite alpine ski racers has not been reported and may be influenced by specific injury characteristics.

Purpose: To report the performance statistics of elite ski racers before and after ACLR and to identify surgical and athlete-specific factors that may be associated with performance recovery.

Study Design: Descriptive epidemiological study.

Goals of Care Discussion Characteristics and Disparities in Children with Medical Complexity.

Objectives: Children with medical complexity (CMC) have disproportionately high healthcare utilization and mortality. Goals of care (GOC) discussions improve goal-concordance and subjective outcomes for CMC and their caregivers; however, little is known about the frequency or characteristics of GOC discussions in CMC. We sought to define GOC discussion frequency and attributes in CMC and identify patient characteristics that may influence GOC discussion occurrence.

PRMT5 Inhibition Reduces Hyperinflammation in a Murine Model of Secondary Hemophagocytic Lymphohistiocytosis (HLH).

Hemophagocytic lymphohistiocytosis (HLH) is a rare but aggressive and potentially lethal hyperinflammatory syndrome characterized by pathologic immune activation and excessive production of proinflammatory cytokines leading to tissue damage and multisystem organ failure. There is an urgent need for the discovery of novel targets and development of therapeutic strategies to treat this rare but deadly syndrome. Protein Arginine Methyltransferase 5 (PRMT5) mediates T cell-based inflammatory responses, making it a potential actionable target for the treatment of HLH.