Publications by authors named "M A Joore"
Repurposing off-patent drugs can be a potential source of low-cost treatments for patients with unmet medical needs. Here, we review the proposed new European Union (EU) pharmaceutical legislation in which two articles address drug repurposing. We find certain barriers hindering the adoption of these new incentives by academic and not-for-profit stakeholders, including lack of knowledge on regulatory aspects, pharmacovigilance, and restrictions in data protection.
View Article and Find Full Text PDFArticle Synopsis
- Total knee arthroplasty (TKA) is commonly used for end-stage osteoarthritis, creating a rising healthcare burden that could intensify with an increasing number of surgeries.
- A state-transition model was crafted to analyze the effectiveness and costs of five hypothetical interventions aimed at reducing TKA needs, focusing on areas like avoiding surgeries and improving patient satisfaction.
- Findings revealed significant cost savings associated with interventions that prevent TKAs and revisions, particularly benefiting younger patients, highlighting potential innovations that could maximize the value of care while reducing the reliance on surgical procedures.
Comprehensive Genomic Profiling (CGP) allows for the identification of many targets. Reimbursement decision-making is, however, challenging because besides the health benefits of on-label treatments and costs, other factors related to diagnostic and treatment pathways may also play a role. The aim of this study was to identify which other factors are relevant for the technology assessment of CGP and to summarize the available evidence for these factors.
View Article and Find Full Text PDFEffectiveness of the Assessment of Burden of Chronic Conditions (ABCC)-tool in patients with asthma, COPD, type 2 diabetes mellitus, and heart failure: A pragmatic clustered quasi-experimental study in the Netherlands.
Eur J Gen Pract
December 2024
Background: The Assessment of Burden of Chronic Conditions (ABCC)-tool was developed to optimise chronic care.
Objectives: This study aimed to assess the effectiveness of the ABCC-tool in patients with COPD, asthma, type 2 diabetes, and/or heart failure in primary care in the Netherlands.
Methods: The study had a pragmatic, clustered, two-armed, quasi-experimental design.
Challenges in the Assessment of a Disease Model in the NICE Single Technology Appraisal of Tirzepatide for Treating Type 2 Diabetes: An External Assessment Group Perspective.
Pharmacoeconomics
August 2024