[Prognostic factors in neuroblastoma in children].

The results of clinico-morphological studies of 152 cases of neuroblastoma are presented. Neuroblastoma should be regarded as a tumor in which the following patterns may be distinguished: sympatogonioma (2.6%), sympatoblastoma -1 (38.

[Changes in the nervous system in kidney diseases].

A total of 150 patients with renal pathology (chronic glomerulonephritis, pyelonephritis, urolithiasis, etc.) accompanied by the development of psychoneurological disturbances were examined. In the initial stage of the renal insufficiency the authors observed neurasthenic, radicular, polyneuritic, renovisceral syndromes, in a more remote stage--encephalopathies and disturbances of the brain circulation.

[Role of the individual sensitivity to various cytostatic agents in children with neuroblastomas].

Primary plasmic cultures of 33 tumors of the sympathic nervous system of children (27 neuroblastomas and 6 ganglioneuromas) were used for determination of their individual sensitivity to vincristin, vinblastin, dactinomycin, mithramycin, olivomycin, cyclophosphant bruneomycin and adriamycin. Most of the tumors were sensitive to vincristin, rubomycin an adriamycin. The data obtained in vitro and in the clinic were compared with respect to 12 cases (treatment with vincristin, combination of olivomycin with cyclophosphan, vincristin with rubomycin or cyclophosphan).