[Postradiation structural changes in the thymocyte and lymphocyte plasma membranes in the fractional irradiation of rats].

On days 1 and 4 after fractionated irradiation of rats with dose of 0.75 Gy changes in thymocyte and lymphocyte plasma membrane structures were studied. Structural parameters of fluorescence probe auramin binding, viscosity of free lipids and lipids bound with integral proteins as well as structural changes of membrane protein structure were determined.

[Effect of autologous blood irradiated in isolation on the restoration of leukopoiesis in an experimental model of prolonged leukopenia].

Reinfusion of irradiated (220 Gy) isolated blood (IIB) was shown to accelerate leukopoiesis restoration in conditions of myelodepression induced by the injection of cyclophosphane. Restoration of leucocyte count in the peripheral blood was preceded by the increase in DNA synthesis and bone marrow cellularity. Reinfusion of IIB also promoted a more rapid restoration of cellularity of lymphoid organs with cAMP predominating therein.

[Structural damages and DNA synthesis in bone marrow and peripheral blood cells in myelodepression induced by cytostatic preparations].

Some structural and functional indices of the genome state of rat myelopoietic cells after cytostatic ingestion are studied by the immunofluorescent method and by 3H-thymidine incorporation. It is shown that administration of cyclophosphamide causes structural and functional damages of hemopoietic cells. It is suggested that the intensity of repair potentials is a leading factor in restoration of depressed hemopoiesis.

[Structural-functional state of the genetic apparatus of blood leukocytes in breast cancer patients during cytostatic therapy].

Functional state of genetic apparatus was studied in leukocytes of patients with carcinoma of mammary gland at the III-IV stage by measuring incorporation of 3H-thymidine into DNA as well as by monitoring impairment of DNA structure using immunofluorescent procedure and antibodies to DNA. The studies were carried out before, in the middle period and at the end of the antitumour chemotherapy. The structure-functional state of genetic apparatus was injured in circulating leukocytes in blood of oncological patients.