Publications by authors named "M A Holly"

Progress in psychiatric treatment has led to important improvements in the quality of life of patients with severe mental illness (SMI). Nevertheless, the life expectancy of patients with SMI remains two decades shorter than that of the general population, and the most prevalent cause of death is cardiovascular disease. Given that the delivery of somatic care to a population of individuals with mental illness is specific, we developed a screening and intervention programme aimed at this vulnerable population.

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Background: Gonorrhea and chlamydia are the most common sexually transmitted diseases (STDs) among men who have sex with men (MSM) in China. Previous studies have shown pay-it-forward (PIF) interventions to be associated with a substantial increase in gonorrhea and chlamydia test uptake compared to standard-of-care. We propose a 'pay-it-forward' gonorrhea and chlamydia testing randomized controlled trial (PIONEER).

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Introduction: The persisting and evolving COVID-19 pandemic has made apparent that no singular policy of mitigation at a regional, national or global level has achieved satisfactory and universally acceptable results. In the United States, carefully planned and executed pandemic policies have been neither effective nor popular and COVID-19 risk management decisions have been relegated to individual citizens and communities. In this paper, we argue that a more effective approach is to equip and strengthen community coalitions to become (LLHCs) that use data over time to make adaptive decisions that can optimize the equity and well-being in their communities.

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Article Synopsis
  • Researchers utilized cryo-electron microscopy (cryo-EM) to determine the full-length structure of the thyroid-stimulating hormone receptor (TSHR) complexed with a human monoclonal autoantibody K1-70™, a potent inhibitor of TSH action.
  • The TSHR was found to have a monomeric structure, displaying three domains: the leucine-rich domain (LRD), hinge region (HR), and transmembrane domain (TMD), with noticeable interactions between the TMD and the extracellular domain (ECD) that explain the effects of TSHR mutations.
  • The study also highlights how the binding of another stimulating autoantibody, M22™, may require the HR to rotate upwards to avoid cl
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Introduction: This paper explores the capabilities that contribute to community transformation and the common pathways followed by communities in the 100 Million Healthier Lives SCALE (Spreading Community Accelerators through Learning and Evaluation) initiative in their transformation journeys towards a "Culture of Health".

Methods: Funded by the Robert Wood Johnson Foundation (RWJF), from 2016 to 2020, between 18 to 24 community coalitions nationwide participated in SCALE, the goal of which was to co-design, implement, test, and scale up a model called the Community of Solutions (COS) Framework, that built community capacity around a set of skills and behaviors to advance culture change and create sustainable improvement in health, well-being, and equity. We adapted and applied two qualitative research techniques, meta-ethnography and participatory action synthesis, to evaluate SCALE initiative data.

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