Publications by authors named "M A Hohenhaus"
Background: Peripheral nerve sheath tumors (PNSTs) encompass entities with different cellular differentiation and degrees of malignancy. Spatial heterogeneity complicates diagnosis and grading of PNSTs in some cases. In malignant PNST (MPNST) for example, single cell sequencing data has shown dissimilar differentiation states of tumor cells.
View Article and Find Full Text PDFBackground: Spinal cord injury (SCI) can impair motor, sensory, and autonomic function. The formation of the glial scar comprises protective as well as inhibitory neurite outgrowth properties operated by the deposition of chondroitin sulfate proteoglycans (CSPG). Chondroitinase ABC (ChABC) can degrade CSPG and foster neuroaxonal plasticity as a therapeutic approach to restore locomotor function after SCI.
View Article and Find Full Text PDFFirst experience using a new minimally invasive screw-rod system for completely percutaneous pedicle screw fixation of the cervical spine.
J Neurol Surg A Cent Eur Neurosurg
November 2024
Article Synopsis
- The study investigates a new minimally invasive technique for placing cervical pedicle screws and rods through small skin incisions, aiming to reduce complications and pain while promoting faster recovery in patients with cervical instability.
- The retrospective analysis included six male patients treated between August 2022 and August 2023, focusing on screw placement accuracy and monitoring for complications.
- Results showed 84.4% of screws were positioned excellently, with no significant neurological issues or revision surgeries, although one patient died from a non-surgical related pulmonary embolism.
To evaluate the efficacy and safety of minimally invasive tubular removal of spinal schwannoma and neurofibroma. In this single-centre study, we retrospectively analysed 49 consecutive patients who underwent minimally invasive removal of a total of 51 benign spinal nerve sheath tumors using a non-expandable (n = 18) or expandable tubular retractor (n = 33) retractor system between June 2007 and December 2019. The extent of resection, surgical complications, neurological outcome, operative time, and estimated blood loss were recorded.
View Article and Find Full Text PDFArticle Synopsis
- PCNSL and GBM are two types of brain tumors that need different treatments, but it's hard to tell them apart using regular MRI scans.
- Researchers used advanced MRI techniques to study the differences between PCNSL and GBM in 20 patients.
- The study found that PCNSL has more cells and preserved brain structures compared to GBM, making it easier to identify the type of tumor with the advanced imaging methods.