Publications by authors named "M A Hernandez-Hernandez"
Objective: The aim of this article is to answer three relevant issues: i/What epileptic condition is referred to as subacute encephalopathy with seizures in alcoholics (SESA) syndrome; ii/ Why it can be important to distinguish SESA syndrome in clinical practice and iii/ What do we know about its pathophysiology.
Methods: We reviewed all cases published in the English language from the initial description of the syndrome to the present. All met the previously established criteria for SESA syndrome were included in our analysis.
Purpose: To describe four patients with subacute encephalopathy with seizures in alcoholics (SESA) syndrome and to review its clinical, electroencephalogram (EEG), neuroimaging and diagnostic criteria.
Methods: We conducted a retrospective analysis of a series of prospectively collected patients who met the previously established criteria for SESA syndrome. Subsequently, we reviewed all cases published in the English language from the initial description to the present.
Article Synopsis
- * There's a problem with the existing studies on plant pathogens in Mexico, as many lack proper scientific backing, making it hard to assess the true presence of these organisms.
- * The review suggests establishing a National Collection of Fungal Cultures and a National Herbarium, along with a comprehensive database to improve understanding and control of plant diseases, which would benefit various fields like quarantine management and biodiversity studies.
Article Synopsis
- Depth electroencephalography (dEEG) is an advanced technique used to monitor brain activity in patients with acute brain injuries, allowing for the detection of nonconvulsive seizures (NCSzs) that might not be seen on traditional scalp EEG.
- In a study of 33 adults, a significant number (about 66%) showed highly epileptiform patterns, but only 27% of those with electrographic seizures had clear scalp correlates; subtle clinical signs were observed during seizures.
- The findings suggest that while many critical patients experience NCSzs, these seizures can often go unnoticed by standard EEG monitoring, highlighting the need for more sensitive detection methods in clinical settings.
Effective, unbiased, high-throughput methods to functionally identify both class II and class I HLA-presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite to diagnostic and therapeutic applications, yet remain underdeveloped. Here, we present T-FINDER [T cell Functional Identification and (Neo)-antigen Discovery of Epitopes and Receptors], a system to rapidly deconvolute CD4 and CD8 TCRs and targets physiologically processed and presented by an individual's unmanipulated, complete human leukocyte antigen (HLA) haplotype. Combining a highly sensitive TCR signaling reporter with an antigen processing system to overcome previously undescribed limitations to target expression, T-FINDER both robustly identifies unknown peptide:HLA ligands from antigen libraries and rapidly screens and functionally validates the specificity of large TCR libraries against known or predicted targets.
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